Podocyte-specific expression of cre recombinase in transgenic mice
نویسندگان
چکیده
منابع مشابه
Podocyte-specific expression of cre recombinase in transgenic mice.
We report a transgenic mouse line that expresses Cre recombinase exclusively in podocytes. Twenty- four transgenic founders were generated in which Cre recombinase was placed under the regulation of a 2.5-kb fragment of the human NPHS2 promoter. Previously, this fragment was shown to drive beta-galactosidase (beta-gal) expression exclusively in podocytes of transgenic mice. For analysis, founde...
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Conventional silencing of many podocyte-specific genes in mice is associated with embryonic or perinatal lethality. Therefore, it would be of great importance to generate mouse models that allow the modification of genes that are expressed in podocytes at later stages of age. Herein is described a transgenic mouse with doxycycline-inducible podocyte-specific expression of Cre recombinase. For t...
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ژورنال
عنوان ژورنال: genesis
سال: 2002
ISSN: 1526-954X,1526-968X
DOI: 10.1002/gene.10164